Faculty Focus - Clement Hamani

Clement Hamani, PhD

Dr. Clement Hamani received his medical degree from Escola Paulista de Medicina in São Paulo in 1993 and went on to receive his PhD in Neurosciences from the same institution. He completed a Research and Clinical Fellowship in Functional Neurosurgery at the Division of Neurosurgery at Toronto Western Hospital. In 2008, he joined the Centre for Addiction and Mental Health as a Research Associate and became Assistant Professor at the University of Toronto Division of Neurosurgery. In 2013, he won the Ohye Award, awarded by the World Society for Stereotactic and Functional Neurosurgery (WSSFN) to promote clinical research in stereotactic and functional neurosurgery. He is currently Associate Professor at the Division of Neurosurgery and a Board Member and Chair of the Guidelines Committee at the American Society for Stereotactic and Functional Neurosurgery. His research focuses on the treatment of movement disorders, epilepsy, and psychiatric disorders.

Current Appointments

  • Associate Professor, Department of Surgery, University of Toronto
  • Affiliate Neuroscientist, Division of Neurosurgery, University of Toronto

Selected Professional Activities


  • Board Member, American Society for Stereotactic and Functional Neurosurgery
  • Chair – Guidelines Committee, American Society for Stereotactic and Functional Neurosurgery

Selected Peer-Reviewed Funding


  • Ontario Mental Health Foundation, 2012-2014
    Antidepressant effects of chronic deep brain stimulation in rats: Neurogenesis dependent and independent mechanisms
    Role: Principal Investigator
  • FAPESP/Pronex, 2012-2016
    Multimodal investigation in epileptogenesis focusing on new models and experimental tools
    Role: Collaborator
  • Canadian Institutes of Health Research, 2011-2015
    Antidepressant effects of deep brain stimulation and the serotonergic system
    Role: Principal Investigator
  • ERA NET- Canadian Institutes of Health Research, 2011-2015
    Describing pathophysiology to promote a focal therapy for the treatment of schizophrenia – an animal experimental study
    Role: Co- Principal Investigator

Selected Publications


  • Reznikov R, Diwan M, Nobrega JN, Hamani C. Towards a better preclinical model of PTSD: characterizing animals with weak extinction, maladaptive stress responses and low plasma corticosterone. J Psychiatr Res. 2015 Feb;61:158-65.
  • Hamani C, Amorim BO, Wheeler AL, Diwan M, Driesslein K, Covolan L, Butson CR, Nobrega JN. Deep brain stimulation in rats: different targets induce similar antidepressant-like effects but influence different circuits. Neurobiol Dis. 2014 Nov;71:205-14.
  • Hamani C, Pilitsis J, Rughani AI, Rosenow JM, Patil PG, Slavin KS, Abosch A, Eskandar E, Mitchell LS, Kalkanis S. Deep brain stimulation for obsessive-compulsive disorder: systematic review and evidence-based guideline sponsored by the American Society for Stereotactic and Functional Neurosurgery and the Congress of Neurological Surgeons (CNS) and endorsed by the CNS and American Association of Neurological Surgeons. Neurosurgery. 2014 Oct;75(4):327-33; quiz 333.
  • Covolan L, de Almeida AC, Amorim B, Cavarsan C, Miranda MF, Aarão MC, Madureira AP, Rodrigues AM, Nobrega JN, Mello LE, Hamani C. Effects of anterior thalamic nucleus deep brain stimulation in chronic epileptic rats. PLoS One. 2014 Jun 3;9(6):e97618.
  • Hamani C, Giacobbe P, Diwan M, Balbino ES, Tong J, Bridgman A, Lipsman N, Lozano AM, Kennedy SH, Nobrega JN. Monoamine oxidase inhibitors potentiate the effects of deep brain stimulation. Am J Psychiatry. 2012 Dec;169(12):1320-1.
  • Hamani C, Temel Y. Deep brain stimulation for psychiatric disease: contributions and validity of animal models. Sci Transl Med. 2012 Jul 11;4(142):142rv8.
  • Hamani C, Machado DC, Hipólide DC, Dubiela FP, Suchecki D, Macedo CE, Tescarollo F, Martins U, Covolan L, Nobrega JN. Deep brain stimulation reverses anhedonic-like behavior in a chronic model of depression: role of serotonin and brain derived neurotrophic factor. Biol Psychiatry. 2012 Jan 1;71(1):30-5.
  • Hamani C, Stone SS, Garten A, Lozano AM, Winocur G. Memory rescue and enhanced neurogenesis following electrical stimulation of the anterior thalamus in rats treated with corticosterone. Exp Neurol. 2011 Nov;232(1):100-4.
  • Hamani C, Mayberg H, Stone S, Laxton A, Haber S, Lozano AM. The subcallosal cingulate gyrus in the context of major depression. Biol Psychiatry. 2011 Feb 15;69(4):301-8.
  • Hamani C, Diwan M, Macedo CE, Brandão ML, Shumake J, Gonzalez-Lima F, Raymond R, Lozano AM, Fletcher PJ, Nobrega JN. Antidepressant-like effects of medial prefrontal cortex deep brain stimulation in rats. Biol Psychiatry. 2010 Jan 15;67(2):117-24.
  • Hamani C, McAndrews MP, Cohn M, Oh M, Zumsteg D, Shapiro CM, Wennberg RA, Lozano AM. Memory enhancement induced by hypothalamic/fornix deep brain stimulation. Ann Neurol. 2008 Jan;63(1):119-23.
  • Hamani C, Schwalb JM, Rezai AR, Dostrovsky JO, Davis KD, Lozano AM. Deep brain stimulation for chronic neuropathic pain: long-term outcome and the incidence of insertional effect. Pain. 2006 Nov;125(1-2):188-96.